Biochemistry
DEPARTMENT OF BIOCHEMISTRY |
Biochemistry is the application of the understanding of chemical principles to mechanisms of biological processes. It is both a life science as well as a chemical science;thus, it spans a wide diversity as a discipline. This relatively modern subject started to become a discipline in its own right only around the beginning of the 20th century when scientists could combine the rigor of chemistry to the then empirical sciences of biology and physiology to decipher the molecular basis of the all life processes.
In Biochemistry you will learn about the complex organic molecules involved in life processes, and how they interact to create the dynamic living structures like cells, tissues, organs and organisms in good health as well as in disease conditions.
The most obvious applications of biochemistry are in diagnostic clinical biochemistry and biomedical research. All the diseases covered in modern medicine, from disease of blood sugar derangements, to degenerative brain conditions like Alzheimer disease, to dysregulated and destructive tissue growth eg cancer, are studied at molecular and chemical levels in this subject. Biochemistry itself also interfaces into other disciplines of medicine. As for example, how drug molecules abate diseases which will be later covered in more detail in the subject of Pharmacology will also be initiated in this subject.
As a first-year medical student Biochemistry will provide you with a solid foundation for understanding all the subjects of second and third Professional MBBS. Additionally, it will evoke keen interest in basic research, which doctors are encouraged to pursue.
Goal: The overall goal of the undergraduate teaching in biochemistry is to allow students to grasp the concepts of the molecular mechanisms of life processes, and to help them apply this knowledge towards solving clinical problems.
OBJECTIVES:
· Knowledge: At the end of the course, the student shall be able to:
· Explain the molecular and functional organization of a cell and list its subcellular components;
· Outline the structure, function and metabolic network of biomolecules and consequences of their dysfunctions;
· Elucidate the fundamental aspects of enzymology highlighting on clinical and translational applications of this knowledge
· Describe the biochemical aspects of digestion absorption and assimilation of nutrients including mechanisms and consequences of malnutrition.
· Integrate the various aspects of metabolism and their regulatory pathways;
· Explain the biochemical basis of inherited disorders with their associated sequel;
· Describe mechanism involved in maintenance of body fluid and pH homeostasis;
· Outline the molecular mechanisms of gene expression and regulating, the principles of genetic engineering and their application in medicine;
· Summarize molecular concept of body defences and their application in medicine;
· Outline the biochemical basis of environmental health hazards, biochemical basis of cancer and rcinogenesis;
· Familiarize with the principles of various conventional and specialized laboratory investigation and instrumentation analysis and interpretation of a given data;
· Suggest experiments to support theoretical concepts and clinical diagnosis.
At the end of the course the student shall be able to:
· Make use of conventional techniques/instruments to perform biochemical analysis relevant to clinical screening and diagnosis;
· Analyze and interpret investigative data;
· Demonstrate the skills of solving scientific and clinical problems and decision-making.
· Integration: The knowledge acquired in biochemistry shall help the students to integrate molecular events with structure and function of the human body in health and disease.
Teaching Faculty
S. No. |
Name |
Designation |
Mobile/Land Line No. |
Qualification |
Residential address |
E-mail ID |
College Time |
01 |
Dr. Seema Laxman Jawalekar | Professor |
9970435576 | MSc. (Medical) Biochemistry, Ph.D. (Medical) Biochemistry |
Medical College Campus, Pali | seems2april@rediffmail.com | 9 am – 3 pm |
02 |
Vacant |
Associate Professor |
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03 |
Assistant Professor |
9802714788 |
MD Biochemistry |
42 B,Bapu Nagar,Pali,Rajasthan |
dr.garnick@gmail.com |
9 am – 3 pm |
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04 |
Assistant Professor (Designated) |
9799367837 |
MD Biochemistry
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253, Patelon ka Baas, V/P Hemawas, Pali |
shesharampatel@gmail.com |
9 am – 3 pm |
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05 |
Dr.Sukhram Santosh | Senior Demonstrator |
6350035928 |
MBBS |
Assit.professors Qurater, Medical College Campus, Pali |
esar.gehlot@gmail.com |
9 am – 3 pm |
06 |
Dr. Cherry Shambhavi | Senior Demonstrator |
7488173735 |
MBBS |
Pali | cherryshambhavi94@gmail.com | 9 am - 3 pm |
| 07 | Mr Vasudev Sankhala | Senior Demonstrator | 9828747166 | MSc. (Medical Biochemistry) | Pali | vasudevsankhla1@gmail.com | 9 am - 3 pm |
Non-Teaching Staff
S. No. |
Name |
Designation |
Mobile/Land Line No. |
Residential address |
01 |
Mr Deva Ram |
Technician |
7891168049 |
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02 |
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Technician |
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03 |
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Stor Keeper cum Clerk cum Comp Operator |
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04 |
Rajesh Singh |
Lab Attendant |
7665500067 |
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05 |
Mrs.Baby |
Sweeper |
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06 |
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Sweeper |
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Publications :
Sr No. |
Faculty Name |
Publication in Vancouver referencing style |
Pubmed indexed Yes /No |
Scopus indexed |
1. |
Dr Seema Jawalekar |
Psychological distress and risk of diabetes among medical students: A cross sectional study.Medical Journal Armed Forces India.https://doi.org/10.1016/j.mjafi.2021.09.003
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Yes |
Yes |
2 |
Biomedical Waste Management: A Review. International Journal of Medical Science and Current Research (IJMSCR) September-October 2021 Volume 4, Issue 5, Page No: 1178-1190
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Yes |
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3. |
A commentary on Alteration of antioxidant enzymes and oxidative stress in elderly patient. American Journal of Physiology, Biochemistry and Pharmacology 2021 VOL 11, NO.6, PAGE: 12-13.
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4. |
Study of knowledge, perception, and practice of patients regarding fasting requirements for blood glucose testing. International Journal of Medical Research and Review. 9(1): 1-12.2021. |
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5. |
How do the tumour derived exosomes mediate breast cancer metastasis? – a narrative review. Journal of Biochemistry International. 7(1): 19-24, 2020. |
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6. |
Editorial :Progress and Impact of ATBM. Advanced Techniques in Biology & Medicine. (2020) Volume 8,Issue 2 ,April 2020. |
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7. |
Histopathological study of CP angle tumours with clinical features and outcome in tertiary health care centre. Int. J of Scientific Research. Volume-7,Issue-4 , April-2018 |
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8. |
Evaluation of thyroid function in patients with type -2 Diabetes Mellitus. Int. J of Scientific Research. Volume-6, Issue-12, December-2017: 455-457. |
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9. |
Evaluation of laboratory measurements for the clinical assessment of chronic kidney disease. Editorial. Kidney Treat Diagn.November-2017;1(1):1-3.
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10. |
Renal functions in patients with metabolic syndrome. International Journal of Medical Research and Review. November – December, 2018, Vol 6,Issue 08. |
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11. |
A comparison of BMI and Lipid Profile in patients with metabolic syndrome and type 2 Diabetes mellitus. International Journal of Medical Research and Review. Volume 05 2017 Issue 03 March. |
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12. |
A Study Of Liver Functions In Metabolic Syndrome And Type 2 Diabetes Mellitus. International Journal of Medical Research and Review. Volume 04 2016 Issue 04 April. |
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13. |
Association between Serum & urine uric acid levels in patients with diabetes Mellitus. International journal of Recent Scientific Research Vol. 7, Issue, 1, pp. 8430-8436, January,2016 . |
Yes |
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14. |
The Role of self- efficacy and self- concept in Medical Undergraduates’s academic Performance. Journal of Research in Medical Education & Ethics .Vol. 4, No. 3, November, 2014, pp-267-272. |
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15. |
Risk of Cardiovascular Diseases in Diabetes Mellitus and Serum Concentration of Asymmetrical Dimethylarginine. Biochemistry Research International, Volume 2013 (2013), |
Yes |
Yes |
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16. |
Role of natural Inhibitors & promoters in urolithiasis. Asian J Med Cli Sci ,Jan -Apr 2013: 2(1). |
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17. |
Erythrocyte arginase activity in pregnancy and postpartum.Biomedicine.2013; 33(1) : 65- 67. |
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Yes |
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18. |
Urinary Excretion of Glycosaminoglycans in patients with urolithiasis. International Journal of Biochemistry Research & Review. 2013 ; 3(1): 74-81. |
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19. |
Alteration of antioxidant enzymes and oxidative stress in elderly patient. J Investig Biochem. 2013 ; 2(1) : 37- 43. |
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20. |
Urinary citrate excretion in patients with urolithiasis. J Adv Sci Res , 2013,4(1) :34-37. |
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21. |
Effect of Dietary habit & fluid intake in patients with urolithiasis. Annals of Biological Research, 2013, 4 (1):246- 251 . |
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22. |
The Hyperlipoproteinemia - An Approach to Diagnosis and Classification. Editorial, Biochem Physiol 2012, 1:1. |
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23. |
The composition and quantitative analysis of urinary calculi in patients with renal calculi. Nepal Med Coll J 2010; 12(3): 145-148. |
Yes |
Yes |
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24. |
Status of Lipid profile, MDA and protein carbonyl in patients with cardiovascular diseases. Arch. Appl. Sci. Res., 2010, 2 (6): 8- 14. |
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25. |
Evaluation of different urinary constituent ratios in renal stone formers.Annals of Biological Research 2010: volume one: Issue 3, Page No. 50-55 . |
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26. |
Role of Oxidants and Anti Oxidants in Patients with Cardiovascular Diseases. Asian Journal of Medical Sciences 2(4): 181- 184, 2010 . |
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27. |
Twenty four hours urine and serum biochemical parameters in patients with Urolithiasis” Nepal Med Coll J 2010; 12 (1): 5-7. |
Yes |
Yes |
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28. |
Inhibition efficiency of urine towards stone forming minerals, Page: 23-27, International journal of pharma sciences and research volume 1 issue Feb – 2010. |
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29. |
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Relationship of Neutrophil Lymphocyte Ratio (NLR) with Parathyroid Hormone (PTH) in Maintenance Hemodialysis Patients.” Tropical Journal of Pathology and Microbiology 7, no. 1 (2021): 17–25. |
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30. |
“Study of Knowledge, Perception, and Practice of Patients Regarding Fasting Requirements for Blood Glucose Testing.” International Journal of Medical Research and Review 9, no. 1 (2021): 01–12. |
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31. |
Angiogenesis and Roles of Adhesion Molecules in Psoriatic Disease (Chapter 5, p53-121) in Raychaudhuri, Siba P., SmritiRaychaudhuri, and DebasisBagchi (eds) Psoriasis and Psoriatic Arthritis: Pathophysiology, Therapeutic Intervention, and Complementary Medicine.Taylor & Francis, CRC Press: Boca Raton, Florida, USA:2018; (part of Expert Consult), Boca Raton FL, London & NY. © 2018Print ISBN |
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32. |
Dr Garima Gupta |
Beta 2 microglobulin as a marker of diagnosis and disease severity in Non Hodgkin lymphoma., Int J Dent Health Sci 2015; 2(2):294-300. |
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33. |
CA125 in Non Hodgkin’s Lymphoma and its association with severity of the disease. AMIRJ. 2015; 2(4):1- 6. |
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34. |
Significance of Protein Bound Sialic Acid In Alcoholic Liver Disease. International Journal of Interdisciplinary and Multidisciplinary Studies (IJIMS), 2015; 6(2): 8-12. |
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35. |
Prediction of Disease Severity by Beta 2 Microglobulin Levels in Hodgkin Lymphoma. Sch. Acad. J. Biosci., March 2016; 4(3A):230-232 |
Yes |
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36. |
Status of Serum Leptin and Lipid Profile in Newly Diagnosed Psoriasis Patients: A Case Control Study JMSCR. March 2 2016;4(3): 9814-23 |
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37. |
Beta 2 Microglobulin (B2M) As a Marker of Disease Severity and Progression in Acute Myeloid Leukemia (AML). Sch. Acad. J. Biosci., 2016; 4(7):589-594 |
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38. |
A case of hyperargininemia presenting at an unusually less age. Journal of clinical and diagnostic research |
Yes |
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39. |
Introducing of Team Based Learning as an Approach of Reviving Interest in Biochemistry amongst Undergraduate Medical Students-An Exploratory Study. Ann Natl Acad Med Sci (India), 53(3): 157-165, 2017. |
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40. |
Haematological and biochemical changes seen in dengue fever in a tertiary care hospital of northern rajasthan. EJBPS, 2018, Volume 5,Issue 8. |
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41 |
Prognostic significance of serum Beta 2 Microglobulin in Non-Hodgkin Lymphoma. Annals of Oncology, 28, p.x9. Paper ESMOASIA 2017. |
Yes |
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42. |
Genetic engineering: towards gene therapy and molecular medicine. Book: OMICS TECHNOLOGIES AND BIO-ENGINEERING: towards improving quality of life |
Book Chapter |
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43. |
Dr Shesharam Patel |
Study of serum lipid profile level in coronary artery disease patients. International journal of medical and biomedical studies,2019,volume 3, issue 6 |
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44. |
Study of serum uric acid levels in Preeclampsia.International Journal of medical science and innovative research,2019,volume -4, issue -3. |
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45. |
Mr Vasudev Sankhla |
Biomedical Waste Management: A Review. International Journal of Medical Science and Current Research (IJMSCR) September-October 2021 Volume 4, Issue 5, Page No: 1178-1190 |
Yes |
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46. |
A Comparative Study of Serum Insulin and Insulin resistance in Obese and Obese NIDDM patients , IJMSIR- SEPTEMBER - 2021, VOL – 6, ISSUE - 5, P. NO. 156 – 163. |
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47. |
Comparison of Vitamin D status in postmenopausal women with and without hypothyroidism. International Journal of Health and Clinical Research, 4(20), 425–427. |
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48. |
Interferences in thyroid function tests IJMSCR-MAY- JUNE 2021, VOLUME 4, ISSUE 3; PAGE NO 992-997. |
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49. |
THYROID FUNCTION TESTS: A REVIEW”, IJSR, OCTOBER – 2021, VOLUME – 10, ISSUE - 10 ,PRINT ISSN NO. 2277 – 8179 |
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50. |
To Study the comparison of Liver function variables among Type-2 Diabetic Patients and Non diabetics subjects in a Tertiary care hospital of Western Rajasthan SCH J APP MED SCI, MAR-2021; 9(3): 367-371. |
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FACILITIES
The Department of Biochemistry at Government Medical College, Pali, is on the ground floor of the academic block. The department has highly qualified faculties in the department.
The Department consist of air conditioned well ventilated and well-lit practical room with instruments and glass wares for students to perform Biochemistry experiments.
The departmental research laboratory is provided with newer instruments.
The departmental library has latest books and journals.
The demonstration room is furnished and equipped with audio-visual aids.
TEACHING ACTIVITIES
Approach of teaching will be a combination of didactic lectures, demonstration of experiments, practical classes, problem based learning and small group discussions. Audio-visual aids will be make classes easy to follow.
SYLLABUS
Paper I
1. Molecular, structural and functional description of Cell and subcellular compartments.
2. Chemistry, function and metabolism of important biomolecules including carbohydrates, amino acids & proteins (hemoglobin & myoglobin), lipids, Vitamins, Nucleic acids.
3. Fundamentals of enzymology including regulations and clinical applications
4. Principles of various routine and special laboratory investigations (Organ function tests); Instrumentation: Colorimetr, mmunoassays, chromatography, electrophoresis, application of radioisotopes; related data analysis & interpretation.
Paper II
1. Nutrition: Biochemical basis of digestion and Assimilation.
2. Integration of metabolic pathways and their various aspects including regulation.
3. Molecular principles and medical significance of immunology.
4. Molecular mechanism of gene expression and regulation; principles of genetic engineering and medical applications
5. Biochemical basis of various inherited and acquired disorders (relevant aspects of 1 &2 and, biological oxidation, detoxification,carbohydrates, lipids, proteins, nucleic acids, vitamins, minerals), plasma proteins, iron metabolism, calcium homeostasis, basics of biochemical endocrinology.
6. Biochemical principles of osmolarity, electrolyte & pH homeostasis
7. Biochemical principles of environmental health hazards including carcinogenesis
8. Experiments to verify theoretical concepts and clinical diagnosis.
SUGGESTED TEXT BOOKS:
1. Harper's Illustrated Biochemistry 31st Edition (Rodwell et al), McGraw-Hill Education, 2018
2. Textbook of Biochemistry for Medical Students 8th Edition (Vasudevan et al), JP Medical Ltd, 2016
3. A Comprehensive Textbook of Medical Biochemistry (Rajinder Chawla et al), United India Periodicals 2012
SUGGESTED REFERENCE BOOKS:
1. Text Book of Biochemistry by Pankaj Naik
2.Lippincott Illustrated Reviews: Biochemistry (Ferrier et al) Wolters Kluwer, 2017
3. (Lehninger) Principles of Biochemistry 7th edition (Nelson et al), Freeman 2017
4. (Stryer) Biochemistry 8th Edition (Berg et al), Freeman 2015
SUGGETSED BOOKS FOR PRACTICALS:
1. Practical Biochemistry 5th Edition (R.C. Gupta et al ) CBS Publisher 2013
CME Programe/ By Dept of Biochemistry
A CME Programme has been organized by the Biochemistry Department
Current trends in Clinical Biochemistry Investigations on 23/08/2019 at Bangur Hospital Auditorium , Pali.
Date: |
23August 2019 |
Topic: |
Introduction to basics of quality control |
Speaker: |
Dr Seema Jawalekar |
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Session -1 |
Topic: |
Genomics,Transcriptomics,Proteomics,Metabolomics- Basic concepts for clinicians |
Speaker: |
Dr.Praveen Sharma,Professor & Head, Dept of Biochemistry,AIIMS, Jodhpur |
Session -2 |
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Topic: |
Investigations in Diabetes |
Speaker: |
Dr. Preet Kaur, Medical Adviser, Transasia |
Session -3 |
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Topic: |
Sample Handling &Good Laboratory practices for Clinicians & Laboratorians |
Speaker: |
Dr. Jairam Rawtani ,Professor& Head, Dept of Biochemistry, S N Medical College, Jodhpur |
Topic: |
Preanalytic Errors in Laboratories |
Speaker: |
Dr AsmitaHazra |
HOSPITAL SERVICES
CLINICAL BIOCHEMISTRY LABORATORY
Clinical Biochemistry laboratory is located at Bangur Hospital, Pali. The laboratory has fully automated biochemical analysis for all tests for diagnosis and monitoring of diseases. The laboratory provides the range of routine assays such as renal, bone, liver, lipid and cardiac profiles.
Majority of investigation are free under state government schemes viz. Mukhyamantri Nishulk Janch Yojna, Janani Shishu Suraksha Yojana and Bhamashah Bima Yojna. Various diseases can be diagnosed by the analysis of body fluids such as blood, CSF, ascitic, pleural and urine.
The laboratory operates on 24 hours, 7 days per week basis.
EQUIPMENTS AVAILABLE IN THE CLINICAL BIOCHEMISTRY LAB
1 |
Fully automatic Biochemistry analyser (ERBA XL 300) |
2 |
Electrolyte analyser (Prolyte) |
3 |
Semi Autoanalyser (ERBA CHEM V SR) |
4 |
Centrifuge (Remi R303) |
5 |
Refrigerator (Haier 300 litre double door) |
6 |
Glucometer |
7 |
Incubator |
8 |
Micropippettes |
9 |
Flame photometer |
10 |
Digital colorimeter 8 filter (Oxford) |
| 11 | Biochemistry Analyser AU480 Maglumi chemiluminescence 800 ABG Analyser (NOVA) CRP Analyser ( Abbott) -200c Refrigerator HLD Generator Hot air Oven |
LIST OF INVESTIGATIONS DONE IN BIOCHEMISTRY DEPARTMENT
S.No |
Name of Test |
1 |
Blood Sugar |
2 |
S Urea |
3 |
S Creatinine |
4 |
S Bilirubin (T) |
5 |
S Bilirubin (D) |
6 |
SGOT |
7 |
SGPT |
8 |
S Alkaline Phosphatase |
9 |
S Total Protein |
10 |
S Albumin |
11 |
S Uric Acid |
12 |
Lipid Profile |
13 |
S Total cholesterol |
14 |
S Triglycerides |
15 |
S. HDL |
16 |
S VLDL |
17 |
S LDL |
18 |
S CK-NAC |
19 |
S. CKMB |
20 |
S LDH |
21 |
S Amylase |
22 |
S Lipase |
23 |
S GGT |
24 |
S. Electrolytes |
25 |
S Calcium |
26 |
S Inorganic Phosphorus |
27 |
CSF (protein, sugar) |
28 |
Body Fluids |
| 29 |
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