1.Evaluation of therapeutic response of multidrug therapy regimens in cases of leprosy

Dr. Madan Singh Batar (Associate Professor Skin and VD)

Dr. Madan Singh Batar¹, Dr. Dinesh Mathur²,

Dr. Prashant Purohit³ & Dr. *Taruna Swami⁴

*Corresponding author

1,2 Department of Dermotology, STD & Leprosy

SMS Medical College & Hospitals, Jaipur

3, Department of Microbiology, S.M.S. Medical Colelge & Hospitals, Jaipur

4 Department of Microbiology, S.P.Medical College, Bikaner

ABSTRACT

INTRODUCTION

Leprosy is a chronic infectious diseases of skin and nerves. Multidrug therapy( MDT) has been backbone of leprosy elimination strategy for last 20 years and this therapy is extremely well accepted all over the world.  Failure of MDT is also reported from various parts of the world as low as 0.77% to as high as 20%.

AIM & OBJECTIVE

To evaluate the therapeutic response of multidrug therapy regimens in cases of leprosy and to observe  the clinical, histopathological and microbiological evidence of disease after completion of therapy.

MATERIAL & METHOD

2.   EVALUATION OF AETIOLOGY OF HAND ECZEMA BY PATCH TEST

Dr. M.S. Batar and *M.S. Kohli
Department of Dermatology, Venereology & Leprology,
S.M.S. Medical Colelge & Hospitals, Jaipur
*Author for Correspondence

ABSTRACT
Introduction: Hand eczema is common chronic multi factorial dermatoses. More than 2% of population
is likely to develop hand eczema at some point of time during life. Aims & Objectives: To study the
clinical pattern along with duration of hand eczema and to ascertain the etiology by performing patch test.
Material and Method: 200 patients of suspected hand eczema were subjected for detailed history and
clinical examination. Various antigens were tested via patch test to find out probable etiology for hand
eczema. Observation and Discussion: The age range of patients varied from 11-70 years, Construction
workers comprised the largest affected group, allergic contact dermatitis (35%) and irritant contact
dermatitis were common cause of hand eczema. Potassium dichromate, nickel sulfate and soap were
found as common allergens.
Keywords: Hand Eczema; Patch Test

INTRODUCTION
The eczema may be induced by a wide range of external and internal factors acting singly or in
combination and it can involve any part of the body. The term hand eczema may not be precise but the
condition is common. For the patient it is a misery which is often chronic and sometimes disabling, for
the dermatologist it means application, time spent and trouble taken to elucidate its etiology.
Hand eczema is a common chronic multi factorial dermatoses More than 2% of population is likely to
develop hand eczema at some point of time during life (Agroup, 1969). Various endogenous and
exogenous factors are involved in the pathogenesis of hand eczema (Duartr et al., 1998).
Contact dermatitis may be an important etiological factor for hand eczema, as large number of substances
comes in contact with hands while working at home or at place of work. Knowledge of pattern of contact
sensitivity in patients of hand eczema may give insight of various etiological agents responsible for it in a
particular area, which can further help in management of these patients. In this study we tried to find out
the factors responsible for hand eczema in our patients.

Aims and Objectives

3. BioMedical and Clinical Research  

Comparative Evaluation of Efficacy of
Clindamycin and Trimethoprim -
Sulfamethoxazole for Treating Patients
with Uncomplicated Skin Infections

Dr. Madan Singh Batar

Senior Specialist (MD), Department of
Dermatology, Venereology & Leprosy,
Government S.K. Hospital, Sikar,
Rajasthan, India.

ABSTRACT

Background: The most common bacterial causes of skin and soft tissue infections (SSTI) are group
A Streptococcus (GAS) and Staphylococcus aureus, the key bacterial agents of impetigo, cellulitis,
abscesses, and wound infections. Aim of the study: To compare efficiency of clindamycin and
trimethoprim-sulfamethoxazole for treating patients with uncomplicated skin infections. Materials &
Methods: The study was conducted in the department of general medicine of the Government S.K.
Hospital, Sikar, Rajasthan, India. . For the study we selected subjects from the surgical ward of the
hospital of the medical institute. The patients diagnosed with uncomplicated skin infection were
included in the study. A total of 42 patients were selected for the study.
Results: A total of 42 patients were enrolled, 21 in group 1 and 21 in group 2. We observed that
clinical cure at 17-20 days was 78.03 % in Group 1 and 74.31 % in group 2. Clinical cure at one
month follow up was 71.22% in group 1 and 65.21% in group 2. Clinical cure in adults in group 1 was
76.2% and in group 2 was 74.84%. Clinical cure in pediatrics was 83.29% in group 1 and 79.35% in
group 2. Clinical cure rate of abscess for group 1 was 77.96% and for group 2 was 81.21%.
Conclusion: Within the limitations of the study we conclude that both the drug combinations i.e.,
clindamycin and trimethoprim-sulfamethoxazole are equally effective in treating uncomplicated skin
infections.
Key words: skin infection, antibiotics, clindamycin, trimethoprim-sulfamethoxazole.

INTRODUCTION___

The most common bacterial causes of skin and soft tissue
infections (SSTI) are group A Streptococcus (GAS) and
Staphylococcus aureus, the key bacterial agents of impetigo,
cellulitis, abscesses, and wound infections.[1] Impetigo is
driven by GAS in resource-poor settings; however, in
developed settings, impetigo, including bullous impetigo, is
more likely to have S aureus present. Although it is difficult to
culture, cellulitis is commonly a GAS infection, whereas S
aureus is consistently recovered from abscess specimens.[2]
Antimicrobial agents that are able to target both GAS and S
aureus are valuable to streamline prescription, improve
adherence, and minimize adverse events, and β-lactam
agents have served this purpose for decades. However, with
the global rise of community-associated methicillin-resistant
S aureus (CA-MRSA), non-β-lactam antimicrobial agents
have become increasingly important.[3,4] One such antibiotic
is sulfamethoxazole-trimethoprim (SXT). Sulfamethoxazoletrimethoprim
is a recommended antibiotic for CA-MRSA
SSTI, but there is an ongoing belief that SXT is ineffective for
GAS SSTI, and dual therapy is often recommended when
GAS may be present.[5,6] Hence, we planned the study to
compare the efficiency of clindamycin and trimethoprimsulfamethoxazole
for treating patients with uncomplicated.

METHODS_

4. Evaluation of Accuracy of Diagnosis of Benign Skin Lesions in
Hospital Practice: An Hospital Based Study

Dr. Madan Singh Batar

Senior Specialist (MD),
Department of Dermatology, Venereology & Leprosy, Government S.K. Hospital, Sikar, Rajasthan, India

ABSTRACT

Background: Skin biopsy is an established diagnostic procedure which connects clinical diagnostic methodology with the invisible to the unaided eye microscopic field of skin pathology. Hence; we planned the present study to evaluate and compare clinical and histopathological diagnosis.
Materials & Methods: The present retrospective study included comparative evaluation of efficacy of clinical diagnosis and histopathological diagnosis. We evaluated the files and records along with biopsy reports of 80 patients with diagnosis of benign skin lesions. Data records of only those patients were included in the present study that was diagnosed with following lesions: Melanocytic Naevi (MN), Seborrhoeic keratosis (SK), viral warts (VW) and Skin tags. Examination of the histopathological reports was done to determine the accuracy of clinical diagnosis. Data regarding the demographic and clinical details of all the patients was obtained. All the results were recorded on Microsoft excel sheet and were analyzed by SPSS software.
Results: Diagnostic accuracy of clinical diagnosis in diagnsoing MN was 88.75 percent, whereas diagnostic
accuracy of SK was 90 percent. Diagnostic accuracy of clinical diagnosis for diagnosing VW and sking tags was 92.5 percent and 91.25 percent respectivley.
Conclusion: It might be unnecessary to confirm the benign skin lesions with histopathologic confirmation.

Key words: Benign, Biopsy, Skin.