Research and Publication Paper
Department Of Genernal Medicine
Randomized Comparative trial Mesuring relative efficacy of glucosamine sulphate, Chondroitin sulphate alone and their combination in knee osteoarthritis
Dr D. Dadhich
Principal specialist, Govt S.K. Medical College, Sikar
Dr D. Bhargav
Senoir Specialist, Govt S.K. Medical College, Sikar
Introduction :
Osteoarthritis is the commonest form of arthritis and most frequent cause of physical disability among elderly population. Osteoarthritis is characterized by the depolymerization of mucopolysachharides, physico chemical alterations of collagen fibers, functional and metabolic change in chondrocytes and abnormal synthesis of proteoglycans. Severaln chondroprotective agents have been introduced in particular the glycosaminoglycans ( GAGS). Among the molecules that have been examined glucosamine sulphate and chondroitin sulphate seem to be capable of interfering with various pathological mechanisms of osteoarthritis stimulating synthetic activity of chondrocytes and inhibiting the chondrolysis provoked by degrading enzymes released in articular cavity during process of osteoarthritis.
Aims and Objectives :
To assess the relative efficacy of glucosamine sulphate, chondroitin sulphate alone and their combination in treatment of knee osteoarthritis
Material and Methods :
The patients who were having clinical and radiologically proved osteoarthritis of knee joint were included in the study. It was randomized comparative study of twelve week duration to measure the relative efficacy of glucosamine sulphate, chondroitin sulphate alone and their combination in management knee osteoarthritis. Patients after selection were carefully screened for exclusion criteria.
Observation :
2.To study the influence of insulin resistance on left ventricular mass in hypertensive patients.
Dr. Darshan kumar bhargava Senior specialist medicine Govt. S.K. Medical College, Sikar.*
Dr. Devendra DadhichPrincipal Specialist medicine Govt. S.K. Medical College, Sikar**
Abstract
Background:- Although LVH is generally associated with hypertension, less then half of hypertensive patients develop LVH. Insulin resistence increase endothelial dysfunction due to increase ACE Activites, which decreases arterial compliance. Various studies have shown that LVM is associated with increase level of Blood Pressure and increase SIPG level.
Material & Methods:-
This is a cross sectional study involving 30 patients who had essential hypertension. SIPG level was assessed by RIA method and M mode Echo was performed to asses LVM.
Conclusion:-
A significant positive correlation was observed between post glucose load serum insulin levels and LV mass in hypertensive subjects.
This association was found to be statistically highly significant (p<0.01) i.e. it was observed that the higher the post glucose load serum insulin levels the greater was the left ventricular mass.
Introduction:
Hypertension is the presence of a raised blood pressure that places individuals at risk for target organ damage in several vascular beds including the brain retina, heart and kidneys. It is a common cause of cardiovascular disease and an essential contributor to cardiovascular morbidity & mortality. The majority of patients with hypertension have primary or idiopathic hypertension and only less than 5% have secondary hypertension.
Material & Methods
The study was conducted on patients suffering from essential hypertension attending the medical OPD and various wards.
3.Randomized Comparative trial Mesuring relative efficacy of glucosamine sulphate, Chondroitin sulphate alone and their combination in knee osteoarthritis
Dr D. Dadhich*,Principal specialist, Govt S.K. Medical College, Sikar
Dr D. Bhargav**,Senoir Specialist, Govt S.K. Medical College, Sikar
Dr Jaya Dadhich***,Resident, Deptt.of Pharmacology,SMS Medical College, Jaipur
Introduction :
Osteoarthritis is the commonest form of arthritis and most frequent cause of physical disability among elderly population. Osteoarthritis is characterized by the depolymerization of mucopolysachharides, physico chemical alterations of collagen fibers, functional and metabolic change in chondrocytes and abnormal synthesis of proteoglycans. Several chondroprotective agents have been introduced in particular the glycosaminoglycans ( GAGS). Among the molecules that have been examined glucosamine sulphate and chondroitin sulphate seem to be capable of interfering with various pathological mechanisms of osteoarthritis stimulating synthetic activity of chondrocytes and inhibiting the chondrolysis provoked by degrading enzymes released in articular cavity during process of osteoarthritis.
Aims and Objectives : To assess the relative efficacy of glucosamine sulphate, chondroitin sulphate alone and their combination in treatment of knee osteoarthritis.
Material and Methods : The patients who were having clinical and radiologically proved osteoarthritis of knee joint were included in the study. It was randomized comparative study of twelve week duration to measure the relative efficacy of glucosamine sulphate, chondroitin sulphate alone and their combination in management knee osteoarthritis. Patients after selection were carefully screened for exclusion criteria.